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About Diarrhea, Nausea,
and Vomiting

OFEV® (nintedanib) may cause serious side effects, including diarrhea, nausea, and vomiting. During your treatment with OFEV capsules, your doctor may recommend that you drink fluids or take medicine to treat these side effects. Always remember to take your OFEV with adequate food.

Treating your symptoms
of diarrhea

Diarrhea is a common side effect of OFEV therapy. In most cases of diarrhea in clinical trials, the majority of patients who had diarrhea were able to remain on OFEV treatment. In severe cases, your doctor may need to stop your OFEV treatment permanently. Tell your doctor immediately if you have diarrhea or if your diarrhea does not go away or becomes severe. Left untreated, diarrhea can lead to dehydration. Severe dehydration can be dangerous because you lose important fluids and minerals. Tell your doctor about all your diarrhea symptoms, especially if you:

  • Have diarrhea and cramps for more than a day
  • Feel dizzy
  • Have a fever
  • Your bottom becomes sore or bleeds

There are prescription and non-prescription over-the-counter medicines that you can take to treat diarrhea. Talk to your doctor before taking medicine for diarrhea. Loperamide is an over-the-counter medicine and is available as Imodium® and Imodium A-D®.

Make sure to talk to your doctor about all of the medicines you are taking. Some medicines, including over-the-counter medicines and dietary supplements, can cause diarrhea. Tell your doctor if you are taking laxatives or stool softeners. Your doctor may make changes to the medicines you are taking to help resolve the diarrhea until it goes away or becomes less severe. Your doctor may also discontinue certain medicines, including OFEV.

Your doctor may also reduce your dose or discontinue OFEV. Your doctor will work with you to help treat side effects in the most appropriate way.

Your diet can make a difference:
The B.R.A.T. diet

The B.R.A.T. diet (Bananas Rice Applesauce Toast) can help you with your diarrhea symptoms. There are also foods that help replace some of the important nutrients that can be lost when you have diarrhea. You may only need to be on the B.R.A.T. diet while you have diarrhea. Please discuss any dietary restrictions with your doctor.

  • Fluids to prevent dehydration
  • Broths, soups, crackers, or pretzels
  • Bananas, potatoes with the skin, and fruit juices to replace potassium
  • Rice, noodles, chicken without the skin, and mashed potatoes to
    reduce fiber
  • Hot or spicy foods
  • High-fiber foods
  • Fried or
    greasy foods
  • Alcohol or caffeine
  • Sugar-free products made with sugar alcohols such
    as xylitol
  • Milk or milk products
Tips to help treat nausea
and vomiting

You should know that OFEV may cause you to feel nauseous or to vomit. Like diarrhea, nausea and vomiting are serious side effects of treatment with OFEV. If you experience either of these symptoms, call your doctor right away. Like diarrhea, they can lead to dehydration and your doctor may recommend that you drink fluids or take medicine to treat nausea and vomiting. There are medicines your doctor can give you to help with these side effects. There are also some things you can do on your own to feel better.

Eat and drink the right
foods and liquids

Nausea is that queasy feeling in the back of your throat or in your stomach. Nausea can result in vomiting, but vomiting may also occur on its own. To reduce this feeling, eat small snacks throughout the day and avoid large meals. Stay away from fatty, fried, spicy, or very sweet foods. Also, try eating food that is cold or at room temperature. Finally, eat foods that are easy on your stomach. These include:

  • Soup
    • Clear chicken, beef, or
      vegetable broth
  • Drinks
    • Flat, clear sodas such as
      ginger ale
    • Cranberry or grape juice
    • Clear tea
    • Water or sports drinks with electrolytes
  • Meals and snacks
    • Broiled or baked (not fried) chicken
      without the skin
    • Farina or oatmeal
    • Pasta or white rice
    • White toast
    • Peeled potatoes
  • Fruits and sweets
    • Bananas or canned fruit such as
      applesauce, peaches, or pears
    • Gelatin
    • Popsicles or sherbet
    • Yogurt
Your environment can affect how you feel

Things in the environment can trigger feelings of nausea or cause you to vomit. After talking with your doctor, there are some things you can do on your own that
may help.

  • Make sense of scents. Some sights, sounds, and odors can make you feel queasy. If they do, be sure to avoid them. If the smell of food bothers you, ask someone to cook for you.
  • Eat right. Eat small snacks throughout the day and avoid large meals. Stay away from fatty, fried, spicy, or very sweet foods. Try eating food that is cold or at room temperature.

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