Tips to Help Treat Diarrhea, Nausea, and Vomiting

The A|I|D Tips to Help Treat Diarrhea, Nausea, and Vomiting Side Effects brochure was developed for patients with idiopathic pulmonary fibrosis (IPF) who are taking OFEV® (nintedanib). This will help you work with your doctor or healthcare provider to help treat the symptoms of diarrhea or nausea and vomiting that may occur when you are taking OFEV capsules. To more effectively treat your symptoms:

Ask your doctor or healthcare provider about diarrhea, nausea, and vomiting and what you can expect during treatment with OFEV. If you are worried or have any questions, ask your doctor what steps you can take at home to deal with or lessen side effects.

Also, tell your doctor about any medicines you are taking. This includes prescription and over-the-counter medicines, vitamins, or dietary and herbal supplements such as St. John's wort. Your doctor will want to make sure that you are NOT taking laxatives, stool softeners, or other medicines and dietary supplements that can cause diarrhea.

Inform your doctor or healthcare provider at the first signs of diarrhea or nausea and vomiting. Be sure to tell them if your symptoms do not go away or become severe. There are a number of things you can do at home to help reduce them. This includes drinking plenty of fluids to prevent dehydration, taking certain medicines, and making changes to your diet. Also, be sure to tell your doctor or healthcare provider whether your symptoms are getting better or worse. They need to know what is working or if they need to do more.


  • Diarrhea or nausea and vomiting can quickly cause dehydration if not treated early. Severe dehydration can be dangerous, so tell your doctor if these symptoms do not go away or become worse, if you develop a fever, or if you feel very weak or confused. Your doctor can give you information about the signs and symptoms of dehydration.
  • There are over-the-counter and prescription medicines you can take to treat diarrhea or nausea and vomiting. Your doctor can recommend the medicine that is best for you.
  • Your doctor may make adjustments to your medicine by reducing your dose of OFEV or briefly stopping your treatment with OFEV until your symptoms improve and you can restart therapy. If your symptoms get better, your doctor will tell you when to restart treatment with OFEV and how much your dose should be. Your doctor may choose to restart OFEV at a lower dose or resume the dose you were taking. Your doctor may also permanently stop OFEV if he or she feels it is appropriate. Never make adjustments to your dose of OFEV on your own. Always speak with your
    doctor first.

Diet can make a big difference in treating diarrhea, nausea, and vomiting. Following the B.R.A.T. diet (Bananas Rice Applesauce Toast) is a good place to start. Remember, you may only need to be on the B.R.A.T. diet while you have diarrhea. Discuss any dietary restrictions with your doctor.

Avoid foods that are spicy, high in fat, fried, or very sweet. Foods that are high in fiber, such as raw fruit, whole grains, vegetables, and nuts, may make diarrhea worse. To help with nausea and vomiting, eat small snacks throughout the day, avoid large meals, or eat food that is cold or at room temperature.

Also, some sights, sounds, and odors can make you feel queasy. If they do, be sure to avoid them. If the smell of food bothers you, ask someone to cook for you. If none of these things seem to work, contact your doctor or healthcare provider.


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